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Discovery of New Biomarker
³²¿µ¼± °­³²Æ÷½ºÆ® Çлý±âÀÚ | ½ÂÀÎ 2020.12.22 20:10

Biomarkers are indicators that can detect changes in the body using proteins, DNA, RNA, and metabolites. It can be used to study various diseases and is also effective in the development of new drugs.

To date, various biomarkers have been studied and used. Recently, the Korea Research Foundation discovered a new protein capable of diagnosing lung cancer. It is also said that it can predict future survival rates. Lung cancer was the cancer with the highest mortality rate and the lowest diagnosis rate so far. Also, since lung cancer has few changes and symptoms in the body, biomarkers were not well found. However, as a result of analyzing lung cancer patients recently, the increase and the decrease in the number of specific proteins were studied.

In particular, the correlation between TRIM28 and RLIM protein was used to analyze the correlation between future survival rates. As a result, it was found that the survival rate of patients with increased TRIM28 and low amounts of RLIM protein was low.

The results of this study will play an important role in future clinical research and are expected to play a crucial role in research for cancer research. These studies are expected to lower lung cancer mortality in the future and have a great impact on pharmaceutical research that will treat them. Furthermore, it appears that it will have a positive effect on researching biomarkers of not only lung cancer but also various related cancers.


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¹ÙÀÌ¿À¸¶Ä¿¶õ ´Ü¹éÁú, DNA, RNA, ´ë»ç ¹°Áú µîÀ» ÀÌ¿ëÇØ ¸ö¾ÈÀÇ º¯È­¸¦ ¾Ë¾Æ³¾ ¼ö ÀÖ´Â ÁöÇ¥¸¦ ¸»ÇÑ´Ù. À̸¦ È°¿ëÇÏ¿© ´Ù¾çÇÑ Áúº´À» ¿¬±¸ÇÒ ¼ö ÀÖÀ¸¸ç ¶ÇÇÑ ½Å¾à°³¹ß¿¡µµ È¿°úÀûÀÌ´Ù.

Áö±Ý±îÁö ´Ù¾çÇÑ ¹ÙÀÌ¿À¸¶Ä¿°¡ ¿¬±¸µÇ¾úÀ¸¸ç »ç¿ëµÇ¾ú´Ù.  ÃÖ±Ù Çѱ¹¿¬±¸Àç´ÜÀº Æó¾ÏÁø´ÜÀÌ °¡´ÉÇÑ »õ·Î¿î ´Ü¹éÁúÀ» ¹ß°ßÇß´Ù. ÀÌ´Â ¶ÇÇÑ ¾ÕÀ¸·ÎÀÇ »ýÁ¸À²µµ ¿¹ÃøÇÒ ¼ö ÀÖ´Ù°í ÇÑ´Ù. Æó¾Ïdms ÇöÀç±îÁö »ç¸Á·üÀÌ °¡Àå ³ô°í Áø´ÜÀ²Àº ¸Å¿ì ³·Àº ¾ÏÀ̾ú´Ù. ¶ÇÇÑ Æó¾ÏÀº ¸öÀÇ º¯È­³ª Áõ»óµµ Àû±â ¶§¹®¿¡ ¹ÙÀÌ¿À¸¶Ä¿ ¶ÇÇÑ Àß ¹ß°ßµÇÁö ¾Ê¾Ò´Ù.

ÇÏÁö¸¸ ÃÖ±Ù Æó¾ÏȯÀÚ¸¦ ºÐ¼®ÇØ º» °á°ú ƯÁ¤ ´Ü¹éÁú ¾çÀÇ Áõ°¡¿Í °¨¼Ò°¡ ¿¬±¸µÇ¾ú´Ù.
ƯÈ÷ TRIM28°ú RLIM ´Ü¹éÁúÀÇ »ó°ü°ü°è·Î ¾ÕÀ¸·ÎÀÇ »ýÁ¸À²ÀÇ »ó°ü°ü°è¸¦ ºÐ¼®Çß´Ù. °á°úÀûÀ¸·Î TRIM28Àº Áõ°¡ÇÏ°í RLIM´Ü¹éÁúÀÇ ¾çÀÌ ÀûÀº ȯÀÚµéÀÇ »ýÁ¸À²ÀÌ ³·Àº °ÍÀ¸·Î ¹àÇôÁ³´Ù.

ÀÌ ¿¬±¸ÀÇ °á°ú´Â ¾ÕÀ¸·ÎÀÇ Àӻ󿬱¸ÀÇ Áß¿äÇÑ ¿ªÇÒÀ» ÇÒ °ÍÀ̸ç, ¾Ï ¿¬±¸¸¦ À§ÇÑ ¿¬±¸ÀÇ °áÁ¤ÀûÀÎ ¿ªÇÒÀ» ÇÒ °ÍÀ¸·Î ±â´ëµÈ´Ù. ÀÌ·¯ÇÑ ¿¬±¸´Â ¾ÕÀ¸·ÎÀÇ Æó¾Ï »ç¸Á·ü ¶ÇÇÑ ³·ÃçÁÖ°í À̸¦ Ä¡·áÇÒ Á¦¾à¿¬±¸¿¡µµ Å« ¿µÇâÀ» ¹ÌÄ¥ °ÍÀ¸·Î ±â´ëµÈ´Ù. ´õ ³ª¾Æ°¡ Æó¾Ï »Ó¸¸ ¾Æ´Ï¶ó °ü·ÃµÈ ´Ù¾çÇÑ ¾ÏÀÇ ¹ÙÀÌ¿À¸¶Ä¿¸¦ ¿¬±¸ÇÏ´Â µ¥¿¡µµ ±àÁ¤Àû ¿µÇâÀ» ¹ÌÄ¥ °ÍÀ¸·Î ³ªÅ¸³µ´Ù.

 

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