Botulinum toxin (Botox), sometimes referred to as Botox, is a prevalent ingredient in anti-aging cosmetics. And how does it operate?

The mechanism behind regular neurotransmitter release must first be understood to comprehend the mechanism of neurotoxins. The presynaptic neuron and the postsynaptic target cell are the two key participants in the process. The synaptic terminal, which is where the neuron contacts the target cell, is where the transaction happens. Small synaptic vesicles at the synaptic terminal hold neurotransmitters. Three proteins together referred to as the SNARE Pin Complex are responsible for keeping these vesicles close to the synaptic terminal membrane. The SNARE Pin fuses the vesicles and membrane in response to stimulation, releasing the neurotransmitters. The actions of the neurotransmitters are then carried out by them when they diffuse across to the target cell.

Image of botox injection, https://www.tthme.com/?category_id=2314514

Botox is a type of clostridial toxin, which is a neurotoxin that actively suppresses the release of neurotransmitters inside neurons. In simple terms, Botox works to cut the SNARE Pin Complex. This prevents the fusion of the synaptic vesicles and neuronal membrane at the synaptic terminal. Thus, the neurotransmitters inside the vesicles cannot be released and attached to their target cells. So, what does this mechanism have to do with wrinkles?

Acetylcholine (ACh), a kind of neurotransmitter that causes muscular contraction, is mostly prevented by Botox. Over time, this leads to the development of noticeable skin wrinkles.

So, keep in mind the actual process behind "Botox" the next time you hear about it!
 

김희 강남포스트 학생기자  webmaster@ignnews.kr

<저작권자 © 강남포스트, 무단 전재 및 재배포 금지>